7-Hydroxymitragynine—commonly known as 7OH—is one of the most powerful alkaloids found in the kratom plant. While it naturally occurs in trace amounts, it plays a major role in kratom’s effects and is increasingly used in concentrated formats like tablets, shots, and disposables.
But how exactly does 7OH work inside the body? What makes it so potent, and how long does it last?
In this blog, we’ll break down:
- How 7OH is metabolized?
- Why is it so powerful?
- How long does its effects typically last?
- And how do these factors influence dosing and safety?
What Is 7OH?
7-hydroxymitragynine is an active alkaloid extracted from the kratom plant (Mitragyna speciosa). It is known for its fast-acting pain relief, mood-lifting effects, and sedation at higher doses. Even though it makes up less than 0.05% of kratom’s raw leaf content, it is up to 10–20 times more potent than morphine in lab models.
It can be taken directly in the form of:
- Tablets or chewables
- Liquid shots
- Disposable vapes
- Powders or capsules
How 7OH Works in the Body
1. Receptor Binding
Once consumed, 7OH travels through the bloodstream and binds to mu-opioid receptors in the brain and nervous system—the same receptors activated by morphine and prescription opioids.
However, 7OH is classified as a partial agonist, meaning:
- It stimulates the receptor, but not to the same extent as full opioids.
- This may reduce the risk of respiratory depression and other severe side effects compared to traditional opioids.
2. Metabolism & Bioconversion
Here’s where it gets even more interesting.
- When you consume kratom, your liver converts mitragynine into 7OH via a process called hepatic metabolism.
- But if you’re taking 7OH directly (e.g., in a tablet or shot), your body skips the conversion step, leading to a faster onset and more targeted effect.
In some cases, 7OH is further metabolized into mitragynine pseudoindoxyl—another powerful compound believed to carry additional analgesic benefits.
3. Elimination
After its effects taper off, 7OH is gradually broken down and eliminated through urine and bile, just like other plant alkaloids.
Why Is 7OH So Potent?
7OH’s strength comes from its:
- High affinity for opioid receptors
- Strong binding efficiency
- Bypassing the mitragynine conversion process
That means even a small dose (like 1–2 mg) can produce noticeable pain relief, relaxation, or euphoria.
Comparison:
| Compound | Potency Relative to Morphine |
| Mitragynine | 10x less potent |
| 7-Hydroxymitragynine | 10–20x more potent |
| Morphine | Baseline |
How Long Does 7OH Last?
General Timeline:
| Phase | Time Frame | What to Expect |
| Onset | 10–30 minutes | Initial effects (relaxation, relief) |
| Peak | 45–90 minutes | Maximum intensity (calm, euphoria, focus) |
| Duration | 4–6 hours | Sustained relief or sedation |
| Come-down | After 5+ hours | Gradual tapering of effects |
Factors That Influence Duration:
- Dose: Higher doses last longer but carry more risk.
- Form: Shots and vapes hit faster, tablets take a bit longer.
- Metabolism: Faster metabolism = shorter duration.
- Empty stomach: Speeds up onset; full stomach slows it down.
Mental & Physical Effects
At Low to Moderate Doses:
- Boosted mood
- Calm mental state
- Mild stimulation or focus
At Higher Doses:
- Sedation
- Strong pain relief
- Sleep support
- Possible dizziness or nausea
Important Safety Tips
- Start Low: Especially with concentrated 7OH tablets or shots.
- Avoid Mixing: Don’t combine with alcohol or CNS depressants.
- Stay Hydrated: Dehydration can worsen side effects like nausea.
- Cycle Use: Take breaks to prevent tolerance or dependency.
- Check Legality: Laws vary by state and country.
Want a High-Quality 7OH Product?
Look for products that:
- Offer accurate, third-party lab testing
- Use pure 7-hydroxymitragynine (not just kratom powder)
- Come from reputable brands like 7Stax, Dozo PERKS, or Zohm
- Clearly label dosage per tablet or serving
Final Thoughts
7OH is a highly potent, fast-acting alkaloid that works by targeting the brain’s opioid receptors—offering serious relief and relaxation. But that power comes with responsibility.
By understanding how it’s metabolized, how long it lasts, and how your body processes it, you can use 7OH safely and effectively. Whether you’re using it for pain, stress, or sleep, always prioritize low doses, clean products, and mindful usage.
Want help choosing the right 7OH tablet or shot? Let me know your use case—I’ll guide you to the best pick.